Molecular Epidemiology of Mycobacterium malmoense Infections in Scotland

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Molecular epidemiology of Mycobacterium malmoense infections in Scotland.

Clinical isolates of Mycobacterium malmoense collected over 5 years from patients across Scotland with a variety of diseases have been characterized by pulsed-field gel electrophoresis (PFGE), ribotyping, and 16S ribosomal DNA gene sequencing. Results indicate that this species harbors little genetic diversity and that the different strain types that were identified by PFGE showed no correlatio...

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Mycobacterium malmoense infections in Scotland: an increasing problem.

During 1982-4 20 cases of Mycobacterium malmoense infection were identified in Scotland (13 male, seven female; age 34-82, median 62 years). Features of the disease were obtained from case notes and radiographs of 19 patients and were found to be indistinguishable from those of patients with pulmonary tuberculosis. Chronic chest disease, predominantly chronic airflow obstruction, was the most f...

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Mycobacterium malmoense bacteremia in two AIDS patients.

We report two cases of Mycobacterium malmoense bacteremia in two patients with AIDS. These are the first reported cases of disseminated M. malmoense in human immunodeficiency virus patients occurring in the United States. This slow-growing organism can cause invasive disease mimicking Mycobacterium avium complex infection; recognition and identification of this organism by mycobacteriology labo...

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Fatty and mycolic acids of Mycobacterium malmoense.

The fatty acids and mycolic acids of 16 clinical isolates of Mycobacterium malmoense were studied by gas chromatography and thin-layer chromatography. All strains contained 2-methyleicosanoic and 2,4,6-trimethyltetracosanoic acids and alpha-, alpha'-, and keto-mycolic acids. The reported findings suggest that lipid analysis is a very useful approach in the species identification of M. malmoense.

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Mycobacterium malmoense: an easily missed pathogen.

The BACTEC system (Becton Dickinson, Sparks, Md.) was compared with culture on Löwenstein-Jensen egg medium for the detection of Mycobacterium malmoense in lymph node samples from children with lymphadenitis. It was found to be significantly more sensitive and rapid. The use of the BACTEC system is thus recommended as a complement to culture on solid media for the primary isolation of atypical ...

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ژورنال

عنوان ژورنال: Journal of Clinical Microbiology

سال: 2002

ISSN: 0095-1137,1098-660X

DOI: 10.1128/jcm.40.3.1103-1105.2002